Breast cancer in particular is believed to be linked to high exposure to estrogen to some degree. One area that has attracted significant interest is in using DIM as a preventative agent for hormone-sensitive cancers. More research is required to determine clinical efficacy in humans. However, most of the results observed so far have been in animal or in vitro trials. It seems to act widely to slow down oncogenesis, inhibit growth of cancer cells and induce natural cellular apoptosis. This natural compound has shown actions against various cancer cell lines. The majority of research data generated to this point concerns the anti-cancer effects of diindolylmethane. DIM Reviews and Anti-Cancer EffectsĭIM research is currently being conducted by the US NCI (National Cancer Institute) to better understand the mechanisms of action that it exhibits.
Currently, both estrogenic and antiestrogenic effects have been linked to DIM administration. In trout experiments, diindolylmethane has been shown to slow down 17-beta-estradiol digestion, making it less estrogenic. It is also believed to upregulate the activity of EROD (ethoxyresorufin O-deethylase), thereby decreasing testosterone 16-alpha. It also changed 4-androstenedione metabolism, leading to estrogen aromatization.įurther, DIM reviews seem to show that it activates protein kinase A-dependent estrogen receptors. In microsomes from rodent livers, diindolylmethane administration lowered the synthesis rates of 16-alpha-hydroxyestrone from estrone. I3C and DIM are believed to promote both Phase 1 and Phase 2 liver metabolism and detoxification. I’ve been recommending it to everyone.” – Sara
#Best dim supplement skin
My skin is clear and my mood swings have abated. Tried every skin care gimmick out there, and did everything I could to naturally balance my hormones. But as soon as I went back down to the regular does (once in AM and once in PM) the headache disappeared.” – mountaingirl I had read several reviews saying that this can happen so I thought it must by the DIM. One night – I started by doubling the dose in the beginning and the first night woke up with the most intense headache I’ve ever had in my life. I’m excited to see how my body continues to adjust in the coming weeks. I’m sleeping like a rock at night, and I think I’ve lost a bit of weight around my mid-section. I have struggled with constant exhaustion for years, and that seems to have disappeared.
“I started taking this t wo weeks ago on the advice of a friend, and my energy levels have gone through the roof.
It also seems to help with cravings a little.” – Dani Cripe “I’ve been using this consistently for about a month, and it has definitely helped my PMS symptoms. Give it 2 months before expecting results though I think I could tell it was working with even less time than that.” – BeautifullyMeInside&Out It grabs up the bad type of estrogen that causes chaos and rids our bodies if it while keeping the healthy estrogen balanced and hormones in harmony. “This should be the go to supplement for hormone balancing in woman. “my skin is clearer, smoother….my cycle?.lighter, no cramps and came normally (26 days vs 23!)…ive even lost a inch or so around my abdomen area (bad bad estrogen!) without working out!” – Shannon The top-rated Nature’s Way DIM-Plus supplement on Amazon has a rating of 4.2 stars out of 5 based on 591 reviews.īelow are some of the comments made by reviewers who have used this product: In user reviews of DIM capsules posted on Amazon and other websites, many women say that this supplement helps to correct these problems. One of the major benefits of DIM supplements is a reduction in estrogen levels among individuals who have high levels.Įxcess estrogen in women can cause a wide range of health problems including increased severity of PMS symptoms, heavier menstrual cycles, irregular cycles, acne, weight gain, bloating, erratic moods and more.
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